Opportunity Information: Apply for PAR 22 234
The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed) is an NIH funding opportunity designed to support research projects that tackle metastasis using systems-level thinking. The core idea behind MetNet is that metastasis is not a simple, linear chain of events, but a complex, dynamic process that unfolds over time and across multiple biological scales. Instead of focusing narrowly on a single pathway, cell type, or isolated step, this program encourages approaches that can explain how metastasis emerges from interacting components in the body, including feedback loops, changing microenvironments, and time-dependent behaviors. In practical terms, the network aims to help the field build a more integrated, whole-body picture of how metastasis starts, progresses, and adapts, with the expectation that this kind of integrated understanding will reveal new points of intervention and sharpen how metastasis is conceptualized as a systems problem.
This opportunity uses the cooperative agreement mechanism (U01), which typically means NIH expects substantial programmatic involvement during the life of the award compared with a standard research grant. Projects funded under this announcement would generally be expected to operate as part of a coordinated research network, contributing insights and outputs that fit into a broader, collective effort rather than functioning as completely standalone studies. The activity area is health and education, and the program is associated with CFDA number 93.396. Clinical trials are explicitly not allowed under this particular announcement, so proposed work should be structured as non-clinical-trial research, even if it involves human-derived data or specimens, provided it does not meet NIH's definition of a clinical trial.
Eligibility is broad and includes many common applicant types across government, academia, nonprofit, and industry. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The announcement also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, tribal governments that are not federally recognized, and non-U.S. entities (foreign organizations). This wide eligibility scope is meant to allow participation from diverse institutions and organizational structures, including international collaborators, as long as they meet the opportunity requirements.
Key administrative details from the listing include the funding opportunity title and number (PAR 22 234), the agency (National Institutes of Health), and that the opportunity is categorized as discretionary funding. The original closing date listed is 2025-06-20. The award ceiling shown is $500,000, indicating the maximum amount expected per award under the parameters provided in the listing. The source data does not specify the exact number of expected awards, but it indicates awards are anticipated. Overall, the opportunity is best understood as support for research projects that contribute to a coordinated network effort to model, measure, and explain metastasis as an evolving system across time and biological scale, using approaches that can capture nonlinearity, dynamics, and emergent behavior without proposing a clinical trial.Apply for PAR 22 234
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "The Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
- This funding opportunity was created on 2022-08-25.
- Applicants must submit their applications by 2025-06-20. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Metastasis Research Network (MetNet): MetNet Research Projects (U01 Clinical Trial Not Allowed) opportunity?
This NIH funding opportunity supports research projects focused on metastasis using systems-level thinking. The program frames metastasis as a complex, dynamic process that unfolds over time and across multiple biological scales, rather than a simple step-by-step chain of events. Projects are expected to contribute to a coordinated research network (MetNet) that aims to build a more integrated, whole-body understanding of how metastasis begins, progresses, and adapts.
Which federal agency is offering this grant?
The agency is the National Institutes of Health (NIH).
What is the funding opportunity number?
The funding opportunity number is PAR 22 234.
What type of funding is this classified as?
The listing categorizes this opportunity as discretionary funding.
What mechanism is used for awards under this opportunity?
This opportunity uses the cooperative agreement mechanism (U01). A U01 typically involves substantial NIH programmatic involvement during the award period compared with a standard research grant.
What does it mean that this is a cooperative agreement (U01)?
Under a cooperative agreement, NIH generally expects to be more actively involved in the program during the life of the award. Funded projects are also generally expected to function as part of a coordinated research network, contributing outputs and insights aligned with a broader collective effort rather than operating as completely standalone studies.
Are clinical trials allowed under this funding opportunity?
No. Clinical trials are explicitly not allowed under this announcement. Proposed work should be designed as non-clinical-trial research.
Can a project use human-derived data or specimens if clinical trials are not allowed?
Yes, the information provided indicates that research may involve human-derived data or specimens as long as the proposed work does not meet NIH's definition of a clinical trial.
What is the main scientific focus of the program?
The program encourages systems-level approaches that can explain how metastasis emerges from interactions among components in the body, including feedback loops, changing microenvironments, and time-dependent behaviors. The intent is to help build an integrated, whole-body picture of metastasis across time and biological scale, with the expectation that this integrated understanding can reveal new points of intervention and refine how metastasis is conceptualized as a systems problem.
Does the program prefer systems-level approaches over single-pathway studies?
Yes. The program description emphasizes moving beyond narrowly focused studies of a single pathway, cell type, or isolated step. It encourages approaches that capture nonlinearity, dynamics, and emergent behavior across multiple scales.
Are funded projects expected to be part of a coordinated network?
Yes. Projects funded under this announcement would generally be expected to operate as part of a coordinated research network and contribute outputs that fit into a broader, collective effort.
What activity area is associated with this opportunity?
The activity area is health and education.
What is the CFDA number associated with this opportunity?
The associated CFDA number is 93.396.
Who is eligible to apply?
Eligibility is broad and includes many applicant types across government, academia, nonprofit, and industry. Eligible applicants include state governments; county governments; city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); Native American tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities.
Are minority-serving institutions specifically highlighted as eligible?
Yes. The announcement highlights eligibility for Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Can faith-based or community-based organizations apply?
Yes. Faith-based or community-based organizations are listed among additional eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are specifically listed among additional eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among additional eligible applicants.
Can tribal governments that are not federally recognized apply?
Yes. Tribal governments that are not federally recognized are explicitly included among additional eligible applicants.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. Non-U.S. entities (foreign organizations) are listed as eligible, indicating international participation is allowed as long as the opportunity requirements are met.
What is the maximum award amount listed for this opportunity?
The award ceiling shown in the listing is $500,000, indicating the maximum amount expected per award under the parameters provided.
How many awards does NIH expect to make?
The source data does not specify an exact number of expected awards, but it indicates that awards are anticipated.
What is the original closing date listed for this opportunity?
The original closing date listed is 2025-06-20.
Is this opportunity intended for standalone projects or collaborative contributions?
Based on the description, the opportunity is intended for projects that contribute to a coordinated network effort. While individual projects will have their own aims, the expectation is that they will align with and feed into a broader, collective effort to understand metastasis as an evolving system.
What kinds of metastasis questions does the program aim to address?
The program aims to support research that models, measures, and explains metastasis as a dynamic, nonlinear process that evolves over time and across biological scales, including how it starts, progresses, adapts, and emerges from interacting components such as feedback loops and changing microenvironments.
What is the practical goal of taking a systems-level view of metastasis?
The description indicates that a systems-level, integrated understanding is expected to reveal new points of intervention and sharpen how metastasis is conceptualized as a systems problem, ultimately advancing the field's ability to understand and address metastatic disease.
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