Opportunity Information: Apply for RFA OH 22 004
The World Trade Center Health Research related to WTC Survivors funding opportunity (RFA OH 22 004) is a federal grant program run under the Department of Health and Human Services through the CDC, with NIOSH administering it in support of the World Trade Center (WTC) Health Program. It is designed to fulfill research requirements set by the James Zadroga 9/11 Health and Compensation Act (the Zadroga Act, as amended), and it reflects research priorities developed in consultation with the WTC Health Program Scientific/Technical Advisory Committee. The main purpose is to fund scientifically rigorous studies focused specifically on people classified as WTC survivors and on closely comparable populations with similar exposures in New York City. A key restriction is stated directly in the title: applications that involve responders are not accepted, meaning the scientific focus must be on survivor cohorts rather than rescue, recovery, or other responder groups.
The research scope centers on understanding and improving outcomes for individuals whose health may have been affected by the September 11, 2001 attacks and their aftermath. Projects are expected to address critical questions about both physical and mental health conditions potentially linked to 9/11-related exposures. The opportunity emphasizes practical, clinically meaningful work in two especially important areas: improving diagnosis where there has been diagnostic uncertainty (for example, conditions where it is difficult to confidently determine WTC-relatedness or to distinguish overlapping syndromes) and improving treatment where there has been treatment uncertainty (for example, limited evidence on what interventions work best for specific WTC-related conditions, subgroups, or comorbid patterns). In other words, the program is not just about documenting risk; it is also about producing findings that can strengthen clinical decision-making and care.
The eligible study population is anchored in enrolled, certified-eligible WTC survivors, including both adults and children. These are individuals who lived, worked, attended school, or participated in child or adult day care within the New York City Disaster Area as defined in federal regulation (42 CFR 88.1) on September 11, 2001 or during the subsequent days, weeks, and months, and who otherwise meet relevant eligibility provisions (such as those described in 42 CFR 88.7 or 88.8) and have been identified as eligible for medical monitoring and treatment under the WTC Health Program. Beyond those certified-eligible survivors, the announcement also allows researchers to include additional sampled populations outside the core disaster area, specifically in Manhattan as far north as 14th Street and in Brooklyn, and it explicitly permits the use of control populations. This broader sampling option is meant to help investigators evaluate whether there are long-term adverse health effects among groups with lower or different exposure profiles and to strengthen causal inference by enabling comparisons.
A major research priority highlighted in the announcement is improving healthcare and overall wellbeing for survivor groups considered at higher risk or historically underrepresented in research and care. The opportunity calls particular attention to minority groups, women who were pregnant at the time of exposure or who were of reproductive age, older adults, adolescents, and other minor children. The emphasis here signals an expectation that applicants will think carefully about inequities in exposure, access to care, comorbidities, social determinants of health, and the ways health impacts may differ by age, sex, pregnancy status, and other factors. Projects that meaningfully address these populations, either through focused recruitment, subgroup analyses, tailored interventions, or improved care delivery approaches, align strongly with the stated interests of the program.
From an administrative and funding standpoint, this opportunity uses a cooperative agreement mechanism (U01). That typically means the funder expects substantial scientific or programmatic involvement during the project period compared with a traditional grant, often including collaboration, milestones, or coordinated activities that support the WTC Health Program mission. The activity category is Health (CFDA 93.262). The award ceiling is listed as $600,000, and the program anticipated making around 5 awards. A wide range of applicants are eligible, including federal-recognized tribal governments and organizations, state and local governments, public housing authorities, independent school districts, public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses, with eligibility described as broadly open to entity types listed in the notice subject to any additional clarifications.
Key dates included a creation date of September 23, 2021 and an original closing date of December 7, 2021, with electronic submissions due by 5:00 PM Eastern Time on the deadline date. Overall, the opportunity is aimed at producing high-quality, actionable evidence on long-term physical and mental health outcomes among WTC survivor populations, with a strong push toward resolving uncertainty in diagnosis and treatment and toward improving care for vulnerable and underserved survivor subgroups in the affected New York City areas.Apply for RFA OH 22 004
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "World Trade Center Health Research related to WTC Survivors (U01-No Applications with Responders Accepted)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.262.
- This funding opportunity was created on Sep 23, 2021.
- Applicants must submit their applications by Dec 07, 2021 Electronically submitted applications must be submitted no later than 500#160pm Eastern Time on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $600,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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