Opportunity Information: Apply for RFA GH 23 001

Enhancing Capacity for Strategic and Applied Research Activities in Support of Control and Elimination of Neglected Tropical Diseases (RFA GH 23 001) is a CDC funding opportunity designed to broaden and strengthen the agency's network of collaborating institutes that can work side-by-side with countries where neglected tropical diseases (NTDs) are endemic, with a particular emphasis on sub-Saharan Africa. The core aim is to build and expand practical research and technical assistance capacity that can directly support national and regional efforts to control and ultimately eliminate selected NTDs and other vector-borne parasitic diseases. Rather than focusing only on generating new academic findings, the opportunity is oriented toward applied work that can be translated into real program improvements, better decision-making, and measurable public health impact in endemic settings.

The award mechanism is a cooperative agreement, which typically means the CDC expects to have substantial involvement with the recipient during implementation. In practice, this structure is commonly used when the funder anticipates ongoing collaboration, technical input, shared planning, or coordinated activities to ensure the work stays aligned with public health priorities. The funding activity category is health, and the opportunity is listed under CFDA 93.326. The notice highlights two major types of work: research synthesis and operational research. Research synthesis generally refers to consolidating existing evidence, such as through systematic reviews, meta-analyses, evidence mapping, or program learning products that clarify what works, under what conditions, and where evidence gaps remain. Operational research is typically the on-the-ground investigation of how to improve the performance, coverage, quality, and efficiency of real-world programs, including questions about delivery strategies, implementation barriers, uptake, adherence, and ways to optimize interventions within routine health systems.

A notable feature of the NOFO is its emphasis on integrated approaches that cross health sectors. This signals interest in strategies that do not treat NTDs in isolation, but instead link them with broader systems and sectors that shape disease transmission and control, such as water, sanitation, and hygiene; vector control; primary health care; environmental management; education; and community-based platforms. The intent is to support approaches that can make NTD activities more sustainable and effective by aligning them with other public health and development efforts, particularly in contexts where resources and workforce capacity are constrained.

Eligibility is broad and includes many types of U.S.-based entities: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (including those other than small businesses); small businesses; and other entities as allowed under the NOFO's additional eligibility language. This wide eligibility suggests CDC is prioritizing access to a range of specialized capabilities, including research institutions, implementing organizations, and technical partners that can operate effectively in collaboration with endemic-country programs.

From a funding standpoint, the opportunity lists an award ceiling of $1,500,000 and anticipates a single award (ExpectedAwards: 1). That combination indicates the CDC likely intends to select one main collaborating institute (or lead applicant) that can serve as a hub for the described research and technical assistance functions, potentially coordinating with partners and stakeholders across multiple countries or program areas. The NOFO was created on November 28, 2022, with an original application deadline of March 10, 2023, and it specifies that electronic submissions were due by 11:59 pm Eastern Time on the deadline date.

Overall, this grant opportunity is best understood as a capacity-expanding and impact-oriented investment: CDC is seeking a partner with strong applied research skills, credibility in global health collaboration, and the ability to produce usable evidence and operational lessons that can improve NTD control and elimination programs. The focus on sub-Saharan Africa, on operationally relevant research, and on cross-sector integration reflects a practical, program-first approach aimed at accelerating progress against diseases that disproportionately affect underserved communities and are often neglected in traditional research and funding portfolios.

  • The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Enhancing Capacity for Strategic and Applied Research Activities in Support of Control and Elimination of Neglected Tropical Diseases" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.326.
  • This funding opportunity was created on Nov 28, 2022.
  • Applicants must submit their applications by Mar 10, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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